Researchers have discovered an immune cell in the human body — known to be important in preventing allergies and other diseases. This cell is also capable of eliminating cancer and fighting viruses like Sars-Cov-2. Corona infection occurs in the human body due to Sars-Cov-2 virus.
These immune cells, called human type-2 innate lymphoid cells (ILCs), can be expanded outside the human body and can defeat tumor survival and eliminate cancer cells. American researchers have obtained this information by experimenting on mice.
The data of this research has been published in the scientific journal ‘Cell’.
Professor Jianhua Yu of the Department of Hematology and Hematopoietic Cell Transplantation of the City of Hope, California, USA, said, ‘In the cell family, we have identified ILC2 cells as a new member that is capable of directly eliminating any type of cancer. Which includes blood cancer and solid tumors.
He also said, ‘In the future, these cells can be produced, stored by freezing and applied to patients’ bodies. T-cell-based therapies such as cART cells, which require the patient’s own cells due to their unique properties—would not be necessary for ILC2S cells. These cells can be collected from a physically healthy donor. That would be a different specialized treatment as allogeneic. Which can be found very easily.
Earlier experiments were conducted with mouse ILC2S cells. However, no promising results were found at that time in terms of cancer eradication in mice cell tests.
But new research has shown that human ILC2S cells work directly to eradicate cancer. But mouse cells can’t do that.
To test human ILC2S cells, Professor Yu and his team first isolated these cells from a blood sample. They have created an innovative platform. which can grow ILC2S cells harvested from the human body up to 200-fold.
They then injected these externally expanded cells into mice with solid tumors. These include pancreatic cancer, lung cancer and glioblastoma. Later experiments showed that these expanded cells could eliminate these tumors.
Professor Yu said, ‘A satisfactory direct proof came when we placed an ILC2 cell and a tumor cell together and found that the tumor cell was eradicated, but the ALC2 cell remained intact.’
“This proves that ILC2S cells directly eradicate cancer cells in the absence of other cells,” added Professor Yu.
Professor Michael Caligiuri, another researcher at the Department of Hematology and Hematopoietic Cell Transplantation in California, said, ‘ILC2S cells are very rare in the human body. It is mostly found in lungs, spleen and skin.’
However, Professor Yu said, the ILC2S cells do not need to be taken from the cancer patient’s own cells. That is, these cells can be collected and stored from another healthy person to treat a cancer patient.
This California researcher said, ‘We dream of applying the results of this research. It can even be applied to diseases other than cancer. ILC2S cells can also act against viruses – such as Covid-19.’